The decreased expression of Beclin - 1 correlates with progression to esophageal 1 adenocarcinoma : The role of deoxycholic acid 2 3
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چکیده
The decreased expression of Beclin-1 correlates with progression to esophageal 1 adenocarcinoma: The role of deoxycholic acid 2 3 Heather B. Roesly, Mohammad R. Khan, Hwu Dau Rw Chen, Kimberly A. Hill, Nirushan 4 Narendran, George S. Watts, Xiaoxin Chen, Katerina Dvorak 5 6 Department of Cellular and Molecular Medicine, Arizona Cancer Center, University of Arizona, 7 Tucson, AZ; ,3 Cancer Research Program, Julius L. Chambers Biomedical Biotechnology 8 Research Institute, North Carolina Central University, Durham, NC 9 10 Running title: Beclin-1 expression in Barrett’s esophagus 11 12 Grant support: The work was supported by the GI SPORE grant CA95060 from NCI. 13 Disclosure: None of the authors on this manuscript declare any conflicts of interest 14 Correspondence: 15 Katerina Dvorak, Ph.D. 16 Associate Professor 17 Department of Cellular and Moleculart Medicine 18 University of Arizona 19 Tucson, AZ 85724 20 Email: [email protected] 21 22 23
منابع مشابه
The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid.
Beclin-1 has a central role in the regulation of autophagy. Barrett's esophagus (BE) is associated with a significantly increased risk for the development of esophageal adenocarcinoma (EAC). In the current study, we evaluated the role of Beclin-1 and autophagy in the EAC. Biopsies obtained from patients with BE and EAC, tissues from a rat model of BE and EAC, and esophageal cell lines were eval...
متن کاملCALL FOR PAPERS Physiology and GI Cancer The response to
TO THE EDITOR: We appreciate the comments of Dr. Yang regarding the problems in the evaluation of autophagy related proteins (Atg) by immunohistochemistry (IHC) or microarray in tissues and their correlation with autophagy activation. In our study entitled “The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid” we found that ...
متن کاملCALL FOR PAPERS Physiology and GI Cancer The response to Dr. Yang
TO THE EDITOR: We appreciate the comments of Dr. Yang regarding the problems in the evaluation of autophagy related proteins (Atg) by immunohistochemistry (IHC) or microarray in tissues and their correlation with autophagy activation. In our study entitled “The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid” we found that ...
متن کاملPathogenesis of Barrett esophagus: deoxycholic acid up-regulates goblet-specific gene MUC2 in concert with CDX2 in human esophageal cells.
HYPOTHESIS Bile acid exposure can induce caudal-related homeobox 2 (CDX2) messenger RNA (mRNA) expression, a transcription factor that plays a crucial role in the development of Barrett esophagus. We investigated mucin 2 (MUC2) and CDX2 mRNA expression before and after treatment with deoxycholic acid in 4 human esophageal cell lines. DESIGN, SETTING, AND PARTICIPANTS Four human esophageal cel...
متن کاملLetter to the editor: Measurement of autophagy-related proteins by immunohistochemistry/tissue microarray to characterize autophagy: problems and considerations.
TO THE EDITOR: In a recent issue of Am J Physiol Gastrointest Liver Physiol, Roesly et al. (10) examined samples of human and murine models of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) to characterize the expression of Beclin 1. Specifically, Roesly et al. found that the expression of Beclin 1 follows a decreasing trend along the continuum from nondysplastic BE to dysplastic ...
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